Assessment of nano-iron particles impact on the reproductive health of female Wistar rats

Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect nano-magnetite on reproductive health female Wistar rats. Twenty-one adult rats were divided into three groups: Group 1 served as control group, 2 received low dose 5 mg/kg and 3 high 10 nano-magnetite. For 30 days, intraperitoneally injected times per week. main findings Revealed that did not induce change body weight or absolute well relative organs weight. Nano-magnetite nanoparticles influenced serum hormone levels imbalanced ovarian uterine malondialdehyde total antioxidant activity. After nanoparticle injection, histopathological examination revealed apoptosis granulosa cells various types follicles, degenerated corpora lutea, congested blood vessels, epithelial tissue showed level inflammation. Immunohistochemistry studies demonstrated significant increase activated caspase-3 following indicating an cell apoptosis. Conclusion This negative magnetite increased likelihood infertility.